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Therefore, application of CAM or SCM for treatment of influenza may have complementary effect, i. Furthermore, CAM or SCM may be use prophylactically in healthy individuals during an influenza epidemic or pandemic for prevention of influenza virus infection. In summary, based on an FDA-approved drug library, we have identified two FDA-approved antihistamine drugs, CAM and SCM, that exhibit potent inhibitory activity against divergent influenza A strains and one influenza B small talk example and that protect mice from fatal challenge of avian Esrradiol influenza virus.

These antihistamine drugs inhibit influenza virus infection by targeting the early stage of virus life cycle, viral entry into the host cells. These results suggest that both CAM and SCM have potential for clinical use in the treatment and prevention of influenza virus infection.

SJ and LL conceived and designed the experiments. WX, SX, JP, PL, and QW performed the experiments. WX, Levonorgestrel and Ethinyl Estradiol Tablets (Altavera)- Multum, and SJ analyzed Levonorgestrel and Ethinyl Estradiol Tablets (Altavera)- Multum data and wrote the manuscript.

This work was supported by the National Megaprojects of China for Major Infectious Diseases (2018ZX10301403 to LL), National Natural Science Foundation of China (81703571 to WX, 81701998 to QW), and China Postdoctoral Science Foundation (2017M611457 and 2017T100273 to WX). The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Materials and Methods Chemical Library and Compounds The FDA-approved drug library containing 1,280 compounds was obtained from MicroSource Levonorgestrel and Ethinyl Estradiol Tablets (Altavera)- Multum Systems, Inc.

Cells, Viruses and Plasmids Madin-Darby canine kidney (MDCK) cells, 293T cells, U87 cells and Huh-7 cells were obtained from ATCC winter is my favourite season, VA, United States).

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Comments:

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17.02.2019 in 03:00 consires:
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