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We are pleased to announce the suggested Update for the 2014 ISSAM recommendations: Investigation, Treatment and Monitoring of late-onset Hypogonadism in Men have now been published online in The Aging Male. Under the Auspices of the European Menopause box johnson Andropause society (EMAS).

GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. Oxford Centre for Evidence-based Medicine Levels of Evidence. Updated by Jeremy Howick March 2009. Going from evidence to recommendations. What are the risks of major cardiovascular events (MACE) from testosterone replacement therapy (TRT).

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J Sex Med, 2016. The decline of androgen levels in elderly men and its clinical and therapeutic implications. Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study. J Clin Endocrinol Metab, 2008. Correlates forest ecology and management journal low testosterone and symptomatic androgen deficiency in a population-based sample.

Genes essential for early events in gonadal development. Cell Mol Life Sci, 1999. Molecular mechanisms of androgen action--a historical perspective.

Methods Mol Biol, 2011. The androgen receptor of the urogenital tract of the fetal rat is regulated by androgen. Mol Cell Endocrinol, 1994. Induction of spermatogenesis by androgens in gonadotropin-deficient (hpg) mice. The effects of exogenously administered testosterone on spermatogenesis in intact and hypophysectomized rats.

Hormonal regulation of spermatogenesis in primates and man: insights for development of the male hormonal contraceptive. Aromatase inhibitors in men: effects and therapeutic options. Reprod Biol Endocrinol, 2011.

Molecular basis of androgen insensitivity. Mol Cell Endocrinol, 2001. Mechanisms of disease: pharmacogenetics of testosterone therapy in hypogonadal men. Nat Clin Pract Urol, 2007. Phenotypic heterogeneity of mutations in androgen receptor gene. Asian J Androl, 2007. Androgen receptor polymorphism (CAG repeats) and androgenicity.

Clin Endocrinol (Oxf), 2005. High prevalence forest ecology and management journal hypogonadism and associated impaired metabolic and bone forest ecology and management journal status in subfertile men. Clin Endocrinol (Oxf), 2016. Semen Quality as a Predictor of Subsequent Morbidity: A Danish Cohort Study of 4,712 Men With Long-Term Follow-up. Am J Epidemiol, 2017. Prenatal and postnatal prevalence of Klinefelter syndrome: a national registry study.

J Clin Endocrinol Metab, 2003. Mol Hum Reprod, 2010. Sequelae of treatment in long-term survivors of testis cancer. Risk factors for post-treatment hypogonadism in testicular cancer patients.

Eur J Endocrinol, 2008. Testosterone deficiency in testicular germ-cell cancer patients is not influenced by oncological treatment.

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